BACCANARI, D. P.: search on Z-Library

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1

X-ray Crystal Structures of Candida a lbicans Dihydrofolate Reductase: High Resolution Ternary Complexes in Which the Dihydronicotinamide Moiety of NADPH Is Displaced by an Inhibitor

Whitlow, Marc, Howard, Andrew J., Stewart, David, Hardman, Karl D., Chan, Joseph H., Baccanari, David P., Tansik, Robert L., Hong, Jean S., Kuyper, Lee F.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 846 KB

english, 2001

2

ChemInform Abstract: 2,4-Diamino-5-benzylpyrimidines and Analogues as Antibacterial Agents. Part 13. Some Alkenyl Derivatives with High in vitro Activity Against Anaerobic Organisms.

ROTH, B., TIDWELL, M. Y., FERONE, R., BACCANARI, D. P., SIGEL, C. W., DEANGELIS, D., ELWELL, L. P.

Journal:

Year:

1990

File:

PDF, 188 KB

1990

3

Peptide agonists of the thrombopoietin receptor

William J. Dower, Steven E. Cwirla, Palaniappan Balasubramanian, Peter J. Schatz, Ronald W. Barrett, David P. Baccanari

Journal:

Year:

1998

Language:

english

File:

PDF, 661 KB

english, 1998

4

Preclinical Development of Eniluracil: Enhancing the Therapeutic Index and Dosing Convenience of 5-Fluorouracil

Melanie T. Paff, David P. Baccanari, Stephen T. Davis, Shousong Cao, Robert L. Tansik, Youcef M. Rustum, Thomas Spector

Journal:

Investigational New Drugs

Year:

2000

Language:

english

File:

PDF, 70 KB

english, 2000

5

ChemInform Abstract: Inhibition of Uridine Phosphorylase: Synthesis and Structure-Activity Relationships of Aryl-Substituted 5-Benzyluracils and 1-((2- Hydroxyethoxy)methyl)-5-benzyluracils.

G. F. ORR, D. L. MUSSO, G. E. BOSWELL, J. L. KELLEY, S. S. JOYNER, S. T. DAVIS, D. P. BACCANARI

Journal:

Year:

1996

File:

PDF, 35 KB

1996

6

α-Fluoro-β-alanine: Effects on the antitumor activity and toxicity of 5-fluorouracil

Shousong Cao, David P Baccanari, Youcef M Rustum, Stephen T Davis, Robert L Tansik, David J.T Porter, Thomas Spector

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 362 KB

english, 2000

7

2,4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 12. 1,2-Dihydroquinolylmethyl analogs with high activity and specificity for bacterial dihydrofolate reductase

Johnson, Jay V., Rauckman, Barbara S., Baccanari, David P., Roth, Barbara

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 978 KB

english, 1989

8

2,4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 9. Lipophilic trimethoprim analogs as antigonococcal agents

Roth, B., Baccanari, D. P., Sigel, C. W., Hubbell, J. P., Eaddy, J., Kao, J. C., Grace, M. E., Rauckman, B. S.

Journal:

Journal of Medicinal Chemistry

Year:

1988

Language:

english

File:

PDF, 1.07 MB

english, 1988

9

Crystal structure of a novel trimethoprim-resistant dihydrofolate reductase specified in Escherichia coli by R-plasmid R67

Matthews, David A., Smith, S. L., Baccanari, D. P., Burchall, J. J., Oatley, S. J., Kraut, J.

Journal:

Year:

1986

Language:

english

File:

PDF, 1.40 MB

english, 1986

10

ChemInform Abstract: RECEPTOR-BASED DESIGN OF DIHYDROFOLATE REDUCTASE INHIBITORS: COMPARISON OF CRYSTALLOGRAPHICALLY DETERMINED ENZYME BINDING WITH ENZYME AFFINITY IN A SERIES OF CARBOXY-SUBSTITUTED TRIMETHOPRIM ANALOGS

KUYPER, L. F., ROTH, B., BACCANARI, D. P., FERONE, R., BEDDELL, C. R., CHAMPNESS, J. N., STAMMERS, D. K., DANN, J. G., NORRINGTON, F. E. A., BAKER, D. J., GOODFORD, P. J.

Journal:

Chemischer Informationsdienst

Year:

1983

File:

PDF, 112 KB

1983

11

Sulfhydryl groups, a factor in the polymorphism of succinyl-CoA synthetase (GDP-forming)

David P. Baccanari, Sungman Cha

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Year:

1974

Language:

english

File:

PDF, 468 KB

english, 1974

12

Methotrexate analogs. 30. Dihydrofolate reductase inhibition and in vitro tumor cell growth inhibition by N.epsilon.-(haloacetyl)-L-lysine and N.delta.-(haloacetyl)-L-ornithine analogs and an acivicin analog of methotrexate

Rosowsky, Andre, Solan, Vishnu C., Forsch, Ronald A., Delcamp, Tavner J., Baccanari, David P., Freisheim, James H.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 1.06 MB

english, 1987

13

Dihydrofolate reductase hysteresis and its effect on inhibitor binding analyses

Baccanari, David P., Joyner, Suzanne S.

Journal:

Year:

1981

Language:

english

File:

PDF, 952 KB

english, 1981

14

Coupled oxidation of NADPH with thiols at neutral pH

David P. Baccanari

Journal:

Archives of Biochemistry and Biophysics

Year:

1978

Language:

english

File:

PDF, 673 KB

english, 1978

15

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs

Kuyper, Lee F., Roth, Barbara, Baccanari, David P., Ferone, Robert, Beddell, Christopher R., Champness, John N., Stammers, David K., Dann, John G., Norrington, Frank E. A.

Journal:

Journal of Medicinal Chemistry

Year:

1982

Language:

english

File:

PDF, 401 KB

english, 1982

16

2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms

Roth, Barbara, Tidwell, Mary Y., Ferone, Robert, Baccanari, David P., Sigel, Carl W., DeAngelis, Diane, Elwell, Lynn P.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 1.29 MB

english, 1989

17

Measurement of the vapor pressures of carbon-14-labeled dodecanoic acid from 20 to 30.deg. using a modified Knudsen effusion method

Baccanari, David P., Yevitz, Marguerite M., Swain, Howard A.

Journal:

Journal of Physical Chemistry

Year:

1968

Language:

english

File:

PDF, 389 KB

english, 1968

18

Substrate-inhibitor cooperative interactions with microbial dihydrofolate reductases

D.P. Baccanari, R.L. Tansik, G.H. Hitchings

Journal:

Advances in Enzyme Regulation

Year:

1987

Language:

english

File:

PDF, 572 KB

english, 1987

19

Inhibition of Uridine Phosphorylase. Synthesis and Structure−Activity Relationships of Aryl-Substituted 1-((2-Hydroxyethoxy)methyl)-5-(3-phenoxybenzyl)uracil

Orr, G. Faye, Musso, David L., Kelley, James L., Joyner, Suzanne S., Davis, Stephen T., Baccanari, David P.

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 228 KB

english, 1997

20

2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 7. Analysis of the effect of 3,5-dialkyl substituent size and shape on binding to four different dihydrofolate reductase enzymes

Roth, Barbara, Rauckman, Barbara S., Ferone, Robert, Baccanari, David P., Champness, John N., Hyde, Richard M.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 2.27 MB

english, 1987

21

X-ray Crystallographic Studies of Candida albicans Dihydrofolate Reductase: HIGH RESOLUTION STRUCTURES OF THE HOLOENZYME AND AN INHIBITED TERNARY COMPLEX

Whitlow, M., Howard, A. J., Stewart, D., Hardman, K. D., Kuyper, L. F., Baccanari, D. P., Fling, M. E., Tansik, R. L.

Journal:

Journal of Biological Chemistry

Year:

1997

Language:

english

File:

PDF, 1.31 MB

english, 1997

22

Species-dependent differences in the biochemical effects and metabolism of 5-benzylacyclouridine

Stephen T. Davis, Suzanne S. Joyner, Pisal Chandrasurin, David P. Baccanari

Journal:

Biochemical Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.14 MB

english, 1993

23

Discussion: Pharmacology and Biochemistry

Then, T., Williams, W., Baccanari, B., Hartman, H., Bowden, B., Brumfitt, B., Schito, S., Gialdroni-Grassi, G., Stephan-Güldner, S.

Journal:

Journal of Chemotherapy

Year:

1993

Language:

english

File:

PDF, 1.66 MB

english, 1993

24

ChemInform Abstract: Selective Inhibitors of Candida albicans Dihydrofolate Reductase: Activity and Selectivity of 5-(Arylthio)-2,4-diaminoquinazolines.

J. H. CHAN, J. S. HONG, L. F. KUYPER, D. P. BACCANARI, S. S. JOYNER, R. L. TANSIK, C. M. BOYTOS, S. K. RUDOLPH

Journal:

Year:

1995

Language:

english

File:

PDF, 38 KB

english, 1995

25

ChemInform Abstract: 2,4-Diamino-5-benzylpyrimidines and Analogues as Antibacterial Agents. Part 12. 1,2-Dihydroquinolylmethyl Analogues with High Activity and Specificity for Bacterial Dihydrofolate Reductase.

JOHNSON, J. V., RAUCKMAN, B. S., BACCANARI, D. P., ROTH, B.

Journal:

Year:

1990

File:

PDF, 208 KB

1990

26

ChemInform Abstract: Synthesis of 1,3-Diamino-7,8,9,10-tetrahydropyrido(3,2-f)quinazolines. Inhibitors of Candida albicans Dihydrofolate Reductase as Potential Antifungal Agents.

J. H. CHAN, J. S. HONG, L. F. KUYPER, M. L. JONES, D. P. BACCANARI, R. L. TANSIK, C. M. BOYTOS, S. K. RUDOLPH, A. D. BROWN

Journal:

Year:

1997

File:

PDF, 34 KB

1997

27

Kinetics of methotrexate binding to dihydrofolate reductase from Neisseria gonorrhoeae

David P. Baccanari, Robert L. Tansik

Journal:

Biochemical Pharmacology

Year:

1984

Language:

english

File:

PDF, 590 KB

english, 1984

28

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs

Kuyper, Lee F., Roth, Barbara, Baccanari, David P., Ferone, Robert, Beddell, Christopher R., Champness, John N., Stammers, David K., Dann, John G., Norrington, Frank E. A.

Journal:

Journal of Medicinal Chemistry

Year:

1985

Language:

english

File:

PDF, 1.20 MB

english, 1985

29

ChemInform Abstract: 2,4-Diamino-5-benzylpyrimidines as Antibacterial Agents. Part 7. Analysis of the Effect of 3,5-Dialkyl Substituent Size and Shape on Binding to Four Different Dihydrofolate Reductase Enzymes.

ROTH, B., RAUCKMAN, B. S., FERONE, R., BACCANARI, D. P., CHAMPNESS, J. N., HYDE, R. M.

Journal:

Year:

1987

File:

PDF, 101 KB

1987

30

ChemInform Abstract: RECEPTOR-BASED DESIGN OF DIHYDROFOLATE REDUCTASE INHIBITORS: COMPARISON OF CRYSTALLOGRAPHICALLY DETERMINED ENZYME BINDING WITH ENZYME AFFINITY IN A SERIES OF CARBOXY-SUBSTITUTED TRIMETHOPRIM ANALOGS

KUYPER, L. F., ROTH, B., BACCANARI, D. P., FERONE, R., BEDDELL, C. R., CHAMPNESS, J. N., STAMMERS, D. K., DANN, J. G., NORRINGTON, F. E., BAKER, D. J., GOODFORD, P. J.

Journal:

Chemischer Informationsdienst

Year:

1985

File:

PDF, 124 KB

1985

31

High-Affinity Inhibitors of Dihydrofolate Reductase: Antimicrobial and Anticancer Activities of 7,8-Dialkyl-1,3-diaminopyrrolo[3,2- f ]quinazolines with Small Molecular Size

Kuyper, Lee F., Baccanari, David P., Jones, Michael L., Hunter, Robert N., Tansik, Robert L., Joyner, Suzanne S., Boytos, Christine M., Rudolph, Sharon K., Knick, Vince, Wilson, H. Robert, Caddell, J.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 317 KB

english, 1996

32

Inhibition of uridine phosphorylase: synthesis and structure-activity relationships of aryl-substituted 5-benzyluracils and 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils.

Orr, G. Faye, Musso, David L., Boswell, G. Evan, Kelley, James L., Joyner, Suzanne S., Davis, Stephen T., Baccanari, David P.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 833 KB

english, 1995

33

Selective Inhibitors of Candida albicans Dihydrofolate Reductase: Activity and Selectivity of 5-(Arylthio)-2,4-diaminoquinazolines

Chan, Joseph H., Hong, Jean S., Kuyper, Lee F., Baccanari, David P., Joyner, Suzanne S., Tansik, Robert L., Boytos, Christine M., Rudolph, Sharon K.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.20 MB

english, 1995

34

Refolding of Recombinant Pneumocystis carinii Dihydrofolate Reductase and Characterization of the Enzyme

C.J. Delves, S.P. Ballantine, R.L. Tansik, D.P. Baccanari, D.K. Stammers

Journal:

Protein Expression and Purification

Year:

1993

File:

PDF, 777 KB

1993

35

5-Ethynyluracil (776C85): Protection from 5-fluorouracil-induced neurotoxicity in dogs

Stephen T. Davis, Suzanne S. Joyner, David P. Baccanari, Thomas Spector

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 320 KB

english, 1994

36

5-Ethynyluracil (776C85): A Potent Modulator of the Pharmacokinetics and Antitumor Efficacy of 5-Fluorouracil

David P. Baccanari, Stephen T. Davis, Vincent C. Knick and Thomas Spector

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 903 KB

english, 1993

37

Heats of sublimation and vaporization at 25� of long-chain fatty acids and methyl esters

Baccanari, David P., Novinski, John A., Pan, Yen-Chi, Yevitz, Marguerite M., Swain, Howard A.

Journal:

Transactions of the Faraday Society

Year:

1968

Language:

english

File:

PDF, 363 KB

english, 1968

38

Synthesis of 1,3-diamino-7,8,9,10-tetrahydropyrido[3,2-f]-quinazolines. Inhibitors of Candida albicans dihydrofolate reductase as potential antifungal agents

Joseph H. Chan, David P. Baccanari, Robert L. Tansik, Christine M. Boytos, Sharon K. Rudolph, Andrew D. Brown, Jean S. Hong, Lee F. Kuyper, Michael L. Jones

Journal:

Journal of Heterocyclic Chemistry

Year:

1997

File:

PDF, 637 KB

1997

39

ChemInform Abstract: 2,4-Diamino-5-benzylpyrimidines and Analogues as Antibacterial Agents. Part 9. Lipophilic Trimethoprim Analogues as Antigonococcal Agents.

ROTH, B., BACCANARI, D. P., SIGEL, C. W., HUBBELL, J. P., EADDY, J., KAO, J. C., GRACE, M. E., RAUCKMAN, B. S.

Journal:

Year:

1988

File:

PDF, 178 KB

1988

40

Discussion: Pharmacology and Biochemistry

Baccanari, B., Williams, W., Hartman, H., Soarva, S., Then, T., Gialdroni-Grassi, G., Bowden, B., Seydel, S., Schito, S., Brumfitt, B., Amyes, A.

Journal:

Journal of Chemotherapy

Year:

1993

Language:

english

File:

PDF, 3.56 MB

english, 1993

41

5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil.

Baccanari, D. P., Davis, S. T., Knick, V. C., Spector, T.

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 1.07 MB

english, 1993

42

Inhibitors of dihydrofolate reductase: Design, synthesis and antimicrobial activities of 2,4-diamino-6-methyl-5-ethynylpyrimidines

Michael L. Jones, David P. Baccanari, Robert L. Tansik, Christine M. Boytos, Sharon K. Rudolph, Lee F. Kuyper

Journal:

Journal of Heterocyclic Chemistry

Year:

1999

File:

PDF, 313 KB

1999

43

Purification and properties of Escherichia coli dihydrofolate reductase

Baccanari, D., Phillips, A., Smith, S., Sinski, D., Burchall, J.

Journal:

Year:

1975

Language:

english

File:

PDF, 832 KB

english, 1975

44

Dihydropyrimidine dehydrogenase inactivation and 5-fluorouracil pharmacokinetics: allometric scaling of animal data, pharmacokinetics and toxicodynamics of 5-fluorouracil in humans

S. P. Khor, H. Amyx, Stephen T. Davis, Donald Nelson, David P. Baccanari, Thomas Spector

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1996

Language:

english

File:

PDF, 176 KB

english, 1996

45

Inhibition of dihydrofolate reductase: effect of NADPH on the selectivity and affinity of diaminobenzylpyrimidines

Baccanari, David P., Daluge, Susan, King, R. W.

Journal:

Year:

1982

Language:

english

File:

PDF, 1021 KB

english, 1982

46

ChemInform Abstract: High-Affinity Inhibitors of Dihydrofolate Reductase: Antimicrobial and Anticancer Activities of 7,8-Dialkyl-1,3-diaminopyrrolo(3,2-f) quinazolines with Small Molecular Size.

L. F. KUYPER, D. P. BACCANARI, M. L. JONES, R. N. HUNTER, R. L. TANSIK, S. S. JOYNER, C. M. BOYTOS, S. K. RUDOLPH, V. KNICK, H. R. WILSON, J. M. CADDELL, H. S. FRIEDMAN, J. C. W. COMLEY, J. N. STABLES

Journal:

Year:

1996

Language:

english

File:

PDF, 34 KB

english, 1996

47

The solubility of 14C-labelled barium carbonate in aqueous systems

David P. Baccanari, Barbara A. Buckman, Marguerite M. Yevitz, Howard A. Swain® Jr.

Journal:

Year:

1968

Language:

english

File:

PDF, 187 KB

english, 1968

48

Pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim

Lee F Kuyper, Janice M Garvey, David P Baccanari, John N Champness, David K Stammers, Christopher R Beddell

Journal:

Bioorganic & Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 876 KB

english, 1996

49

Escherichia coli dihydrofolate reductase: isolation and characterization of two isozymes

Baccanari, David P., Averett, Devron, Briggs, Clark, Burchall, James

Journal:

Year:

1977

Language:

english

File:

PDF, 2.66 MB

english, 1977

50

Dihydrofolate Reductase from Neisseria sp

Averett, D. R., Roth, B., Burchall, J. J., Baccanari, D. P.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

1979

Language:

english

File:

PDF, 1.29 MB

english, 1979

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